Current Funding Announcements

See below

PRE-ANNOUNCEMENT: Department of Defense Congressionally Directed Medical Research Programs (CDMRP) Toxic Exposures Research Program (TERP) Anticipated Funding Opportunities for FY22

PRE-ANNOUNCEMENT: Department of Defense Congressionally Directed Medical Research Programs (CDMRP)

Toxic Exposures Research Program (TERP)Anticipated Funding Opportunities for FY22

Description: The Consolidated Appropriations Act, 2022 provides funding for the TERP to support

innovative, high-impact toxic exposures research. This pre-announcement to allow investigators time

to plan and develop ideas for submission to the anticipated FY22 funding opportunities. The FY22

TERP funding opportunity announcements for the following award mechanisms will be posted on the

Grants.gov website. Pre-application and application deadlines will be available when the

announcements are released.

Applications must address one or more of the Program Goals:

• Elucidate mechanisms of how toxic exposures result in adverse effects

• Diagnose the effects of toxic exposures

• Predict and prevent toxic exposures

• Develop therapeutics, treatments, and strategies

Applications must address one or more Topic Areas, which include Neurotoxin Exposure (e.g.,

long-term disorders, basic mechanisms, prediction/prevention/assessment, innovative treatments,

clinical signs and symptoms or biomarkers, comorbidities). Any proposed exposure must be relevant

to Service Members, Veterans and/or the American public. Areas of encouragement include exposures

to fuels and other petroleum products.

Pre-announcement news release: https://cdmrp.army.mil/pubs/press/2022/22terppreann

About TERP: https://cdmrp.army.mil/terp/default

Anticipated maximum funding/periods of performance

• Investigator Initiated Research Award (IIRA): $500,000/3 years

• Translational Research Award (TRA)

o $800,000/3 years

o Partnership option: $1.6M/3 years

• Clinical Trial Award (CTA)

o $1.5M/4 years

o Partnership option: $2.5M/4 years

Point of Contact: CDMRP Public Affairs, 301-619-9783, usarmy.detrick.medcom-mrp.mbx.cdmrp-public-affairs@mail.mil

fy 22 traumatic brain injury and psychological health research program (TBIPHRP)

W81XWH-22-TBIPHRP: FY22 Traumatic Brain Injury and Psychological Health Research Program (TBIPHRP)

Description: The FY22 Defense Appropriations Act provides funding for TBIPHRP to support research

into the treatment, prevention, and detection of traumatic brain injury (TBI) and improved

psychological health. The TBIPHRP’s vision is to optimize the prevention, assessment, and treatment

of psychological health conditions and/or traumatic brain injuries. Proposed research can be

aligned with TBI, psychological health, or both. The program seeks to fund research that

accelerates solutions to improve the health, well-being, and healthcare of Service Members,

Veterans, military beneficiaries, and the American public. Applications must address one or more

Focus Areas, not all of which will be applicable to every award mechanism:

• Understand: research will address knowledge gaps in foundational science, epidemiology, and

etiology of psychological health conditions and/or TBIs.

• Prevent and Assess: research will address the prevention or progression of psychological

health conditions and/or TBI through population, selective, and indicated prevention approaches,

including efforts that focus on primary prevention, screening, diagnosis, and prognosis.

• Treat: research will address immediate and long-term treatments and improvements in systems

of care, including access to and delivery of healthcare services. Treatment topics may include

novel treatments and interventions, personalized medicine approaches, length and durability of

treatment, rehabilitation, relapse, and relapse prevention. Includes interventions focused on

sensory and motor dysfunction after brain injury.

Maximum funding/periods of performance:

Clinical trial award (CTA)

• Pre-application due September 1, 2022; full application due December 8, 2022

• Funding level 1: $500,000/3 years

• Funding level 2: $2M/4 years

• Funding level 3: $4M/4 years Focused program award (FPA)

• Pre-application due September 1, 2022; full application due December 8, 2022

• $5M/4 years

Investigator initiated research award (IIRP)

• Pre-application due August 24, 2022; full application due September 14, 2022

• $500,000/3 years Translational research award (TRA)

• Pre-application due August 24, 2022; full application due September 14, 2022

• $1M/3 years

Patient-centered research award (PCRA)

• Pre-application due August 24, 2022; full application due September 14, 2022

• $1M/4 years

About TBIPHRP: https://cdmrp.army.mil/tbiphrp/

Full announcements and additional information are available at:

https://www.grants.gov/web/grants/search-grants.html?keywords=TBIPHRP

Congressionally Directed Medical Research Programs (CDMRP) Hearing restoration research program (HRRP) - FY 22 focused research award

W81XWH-22-HRRP-FRA: Congressionally Directed Medical Research Programs (CDMRP) Hearing Restoration

Research Program (HRRP) – FY22 Focused Research Award

Description: The FY22 Defense Appropriations Act provides funding for the Hearing Restoration

Research Program (HRRP) to support innovative and impactful research that pursues the treatment of

auditory system injuries and the restoration of hearing. About HRRP:

https://cdmrp.army.mil/hrrp/default To meet the intent of the award mechanism, all applications to

the FY22 HRRP Focused Research Award (FRA) must address research in one or more of the following

Focus Areas:

• Accelerate translation of biological regeneration/repair mechanisms into therapies that treat

auditory system injury and restore auditory function, for example:

o Hair cell regeneration/repair/recovery

o Neural regeneration/repair/recovery

o Treatment for synaptopathy and hidden hearing loss

• Diagnostic tests that help differentiate sensory, neural, synaptic, and central processing

disorders, that may inform applicability and outcomes for current or future hearing restoration

therapeutics.

• Develop reliable in-vitro human models to facilitate the understanding, derivation, and

characterization of human auditory cells, and/or to facilitate the evaluation of hearing

restoration therapies.

• Develop and/or validate techniques/methods beyond the audiogram to diagnose acute auditory

system injury in austere or remote environments. For example, but not limited to, simple and rapid

assessments that are compatible with portable platforms.

Tinnitus or vestibular-related research is excluded.

A pre-application is required and must be submitted through the electronic Biomedical Research

Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All

applications must conform to the final funding opportunity announcements that will be available for

downloading from the Grants.gov website.

Full award announcement: https://www.grants.gov/web/grants/view- opportunity.html?oppId=340447

Pre-Application Submission Deadline: July 22, 2022 (5:00 p.m. Eastern)

Application Submission Deadline: November 30, 2022 (11:59 p.m. Eastern)

Maximum funding/periods of performance:
Funding level 1: $250,000/2 years
Funding level 2: $1M/3 years

Funding level 3: $1.25M/3 years

Combat Readiness – Medical Research Program Rapid development and translational research award (RDTRA)

Description: The CRRP focuses on forward-deployable solutions that can promptly address life-

threatening injuries, medical threats, and treatments for Warfighters in current and future

battlefield settings, to deliver high-impact medical solutions in diverse operational settings and

closer to the point of injury to increase survivability and Warfighter readiness. The program seeks

to develop innovative solutions to increase medical readiness, mitigate fatalities, optimally treat

life-threatening injuries, and promote positive long-term outcomes. Innovations developed by

CRRP-supported research may be applied proactively as a way to establish medical readiness ahead of

deployment, in operational settings at the point of injury, during periods of prolonged care, or

during transport/ en route between roles of care.

Focus Areas broadly describe current priorities to improve readiness for delivering frontline care

in combat situations and for delivering medical damage control capability, assets, and life- saving

interventions during prolonged and en route care in austere and combat environments, including the

acute and early management of combat-related trauma at the point of injury.

Proposed research must address at least one of the FY22 CRRP Focus Areas; these include

complementary health measures to accelerate return to duty, and regenerative medicine. Focus areas

include solutions to enhance combat care delivery throughout the far-forward environment, such as:

• Telemedicine solutions that enable medical capabilities at far-forward battlespace locations

worldwide

• Medical simulation technology that supports sustainment of critical skills and medical

decision-making

• Solutions for the assessment of mild traumatic brain injury, to include portable and handheld

devices

Proposed research must have the potential for rapid development and translation of applicable

advances for improving medical readiness, mitigating fatalities, optimally treating life-

threatening injuries, and promoting positive long-term outcomes for military health and medicine,

as well as the general public. Supports preclinical research, clinical research, and small-scale

clinical trials (e.g., first in human, phase 1/1b).

Pre-Application (Preproposal) due: June 23, 2022

Proposal/Application due: September 14, 2022

Max Period of Performance: 2 years (3 years with option)

Max Funding: $2.2M total costs (2 years), $1M option year

For more information, full announcements (extramural, intramural), and submission

instructions: https://cdmrp.army.mil/funding/crrp

BRAIN Initiative: Targeted BRAIN Circuits Projects – Targeted BCP (R01 Clinical Trial Not Allowed)

RFA-NS-22-026: BRAIN Initiative: Targeted BRAIN Circuits Projects – Targeted BCP (R01

Clinical Trial Not Allowed)

Description: This FOA solicits applications for research projects that seek to understand how

circuit activity gives rise to mental experience and behavior using innovative, methodologically-

integrated approaches. The goal is to support adventurous projects that can realize a potentially

transformative outcome within 5 years. Applications are expected to address circuit function in the

context of specific behaviors or neural systems, such as sensation, perception, attention,

reasoning, intention, decision-making, emotion, navigation, communication, or homeostasis. Projects

should link theory, data analysis, and/or computational approaches to experimental design and

should produce predictive models (conceptual or quantitative).

Projects should aim to improve the understanding of circuits of the central nervous system by

systematically controlling stimuli and/or behavior while actively recording and/or manipulating

dynamic patterns of neural activity. Diverse species or experimental systems and a cross-

species/comparative approach are welcome and should be chosen based on their power to address the

specific question at hand and to reveal generalizable and fundamental neuroscience principles.

Targeted BRAIN Circuit Project R01 awards will support an individual laboratory or a small

multi-PD/PI team. Projects should reflect the NIH BRAIN Initiative interests of the application of

cutting-edge methodologies to understand central nervous system circuit function and

dynamics at cellular and sub-second levels of resolution in ethologically relevant behaviors of an

organism or a well-defined neural system. Applications should offer specific, feasible, and

potentially transformative research goals as endpoints within a 5-year term

Representative topics include: Innovative approaches to understand network coding of sensory

information and/or multi-sensory integration, at multiple stages of processing, in response to

naturalistic inputs and perceptual contexts.

Letter of Intent due date(s) 30 days prior to the application due date

Application due dates: June 1, 2022; July 1, 2022; October 6, 2022; June 30, 2023; October 4,

2023; June 28, 2024; October 2, 2024

Maximum project period: 5 years

Funding amount: the BRAIN Initiative intends to commit up to an estimated total of $15 M per year

to fund 20 awards.

Information: https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-026.html

NIDCD Research Grants for Translating Basic Research into Clinical Tools (R01 Clinical Trials Optional)

RFA-DC-22-001: NIDCD Research Grants for Translating Basic Research into Clinical Tools (R01 Clinical Trials Optional)

NIH - National Institute on Aging (NIA) and National Institute on Deafness and Other Communication

Disorders (NIDCD)

Description: This Funding Opportunity Announcement (FOA) is intended to provide an avenue for basic

scientists, clinicians and clinical scientists to jointly initiate and conduct translational

research projects which translate basic research findings into clinical tools for better human

health. The scope of this FOA includes a range of activities to encourage translation of basic

research findings which will impact the diagnosis, treatment and prevention of communication

disorders. Connection to the clinical condition must be clearly established and the outcomes of

the grant must have practical clinical impact.

Possible goals include, but are not limited to:

• Biochemical, electrophysiological and behavioral assays to enhance diagnostic capabilities.

• Pharmacology, toxicity, and pharmacokinetic for candidate therapeutics that have demonstrated

potential for the treatment of communication disorders.

• Preclinical animal research for dosage studies and toxicity when a subsequent Phase I/II

clinical trial is planned.

• Translation of new tools and techniques for better diagnostics or therapeutics, including but

not limited to, neuroprosthetic devices, drug delivery devices, neuro-electrical stimulators and

recording devices.

• Translation of laboratory-based screening tests, including biomarkers into improved ways to

identify individuals at risk for a communication disorder to allow for early intervention.

• Translation of published basic research findings into new clinical tools to better target the

treatment to the individual patient and to better predict patient response or prognosis.

• Translation of discoveries from biological, psychological, social sciences and other related

areas into innovative prevention and treatment paradigms and processes.

• Modification of laboratory measures of function or laboratory treatment protocols for use in

clinical settings.

Open Date (Earliest Submission Date): September 17, 2021

Letter of Intent Due Date(s): 30 days prior to the application due date

Application Due Date(s): October 20, 2021; June 20, 2022; February 22, 2023; October 18,

2023; June 20, 2024

Maximum Project Period: 5 years

Maximum Amount: NIDCD anticipates funding an estimated 2-3 awards in fiscal year 2022 for a total

of $1,500,000.

additional Information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DC-22-001.html

Open/Active DoD Broad Agency Announcements

U.S. Army Medical Research and Development Command (USAMRDC) - W81XWH18SBAA1: This BAA is open through September 30, 2022. USAMRDC funds a broad range of extramural research programs through contracts, grants, or cooperative agreements. Proposals can be submitted through the USAMRDC Broad Agency Announcement (BAA) or through special USAMRDC BAA Announcements, which are open for limited timeframes. Additional information, the USAMRDC Broad Agency Announcement, and open special USAMRDC BAA Announcements can be obtained at: https://www.usamraa.army.mil/Pages/BAA.aspx and https://www.grants.gov/web/grants/view-opportunity.html?oppId=297726

U.S. Military Academy Broad Agency Announcement - W911NF-20-S-0008: This BAA was released April 1, 2020, and is open until March 31, 2025. It seeks proposals for cutting- edge innovative research that could produce discoveries with significant impact to enable new and improved Army technologies and related operational capabilities in the areas of socio-cultural; information technology; ballistics, weapons and protections; energy and sustainability; materials, measurements, and facilities; unmanned systems and space; human support systems; and artificial intelligence, machine learning, and quantum technologies. The human support systems focus includes biomechanical engineering to enhance soldier readiness (human performance optimization, injury prediction/prevention, physical and cognitive augmentation, Return-to-Duty metrics, functional influence of prosthetics/exoskeletal devices) and wearable technologies and sensors to inform performance decisions (e.g., monitoring/assessment, injury prevention, recovery times).

See: Military Academy BAA

Research Interests of the Air Force Office of Scientific Research

Announcement: BAA-AFRL-AFOSR-2016-0007
Award Organization: Air Force Office of Scientific Research
Type/Mechanism: Grant
Activity Code:
Web Site: DoD: http://www.grants.gov/web/grants/view-opportunity.html?oppId=285269
Award Amount: $200,000 - $400,000 encouraged; $7.5M max

PoP: 5 years
Restrictions: None
Rolling Annual Programs: Open until Superseded
Pre-Application Due: Open until superseded
Full App Due: Open until superseded
Notes: For the sensory systems portion of the portfolio a goal is to pursue new capabilities in acoustic analysis, to enhance the intelligibility and usefulness of acoustic information. The primary approach is to discover, develop, and test principles derived from an advanced understanding of cortical and sub-cortical processes in the auditory brain. Included are efforts to model and control effects of noise interference and reverberation, understand the psychoacoustic basis of informational masking, develop new methods for automatic speech detection, classification, and identification, and enable efficient 3D spatial segregation of multiple overlapping acoustic sources.

DOD USAMRMC FY18-FY22 Broad agency announcement for extramural medical research

Announcement: W81XWH18SBAA1
Award Organization: U.S. Army Medical Research and Material Commnad's
Type/Mechanism: Grants Notice
Activity Code: USC, Title 10, Section 2358
Web Site: https://www.grants.gov/web/grants/search-grants.html?keywords=W81XWH18SBAA1
Award Amount:
PoP: 4 years
Restrictions:
Rolling Annual Programs:
Pre-Application Due: Oct 1, 2017
Full Application Due : September 30, 2022, 11:59 p.m. ET
Notes: Clinical and Rehabilitative Medicine Research Program focus on the innovations required to reset our wounded Service members, both in terms of duty performance and quality of life. Innovations developed from CRMRP-supported research efforts are expected to improve restorative treatments and rehabilitative care to maximize function for return to duty (RTD) or civilian life.
The CRMRP focuses its efforts on the following research areas: neuromusculoskeletal injury (including limb trauma and amputation), sensory systems impairment (including hearing, balance, tinnitus, and vision), acute and chronic pain, and regenerative medicine.

Research

Quick Fact

#30

Hearing loss affects people of all ages and is often preventable.