Current Funding Announcements

W81XWH-19-CTRR-CRA

DoD Complex Traumatic Brain Injury Rehabilitation Research - Clinical Research Award

Description: The FY19 PH/TBIRP CTRR-CRA is intended to support clinical research focused on understanding the clinical sequelae and mechanisms of recovery associated with mTBI and TBI- related cognitive, sensory, and motor performances. The overarching goals of this award are to address TBI-related impairments and deficits, including multi-modal and cognitive dysfunction, to (1) develop and validate rehabilitation outcome measures; (2) systematically analyze standard of care cognitive interventions to identify optimal treatment ingredients; and (3) improve clinician-driven assessment strategies to guide RTD decision-making. The FY19 PH/TBIRP CTRR-CRA seeks research to develop and validate novel outcome measures that will characterize and track functional cognitive, sensory, and motor performance deficit in Service members and relevant populations with cognitive dysfunction following TBI; and to identify key treatment approaches to optimize cognitive rehabilitation following TBI, as consistent with the mission of the JPC-8/CRMRP.

Supported research should investigate effectiveness of rehabilitation in remediating postconcussive sequelae across the spectrum of known post-concussive vulnerabilities in the areas DoD FY19 PH/TBIRP CTRR – Clinical Research Award 4 of post-traumatic dizziness, vestibular dysfunction, imbalance or dynamic instability; visual and oculomotor dysfunction; cognitive deficits (e.g., degraded processing speed, memory, or executive functioning); central auditory processing; and autonomic dysregulation. Solutions should integrate objective clinical findings in the following domains: cognitive performance, sensory function, and motor performance.

The CRA mechanism supports applied and translational clinical research to advance the development of knowledge and materiel products for rehabilitation and restoration of function following TBI. Clinical trials are not supported by this mechanism. Studies involving animal research do not meet the intent of this award mechanism.

Pre-app due: 10 September 2019

Full app due: 2 December 2019 Period of Performance: 3 years Max Funding: $2M

For more information, https://www.grants.gov/web/grants/view-

opportunity.html?oppId=318673

 W81XWH-19-DMRDP-AIMM - Accelerating Innovation in Military Medicine Research Award

Description: The AIMM initiative was created to accelerate transformational biomedical research for our Armed Forces and Nation. The mission of the AIMM initiative is to encourage, identify, and enable innovative research that leads to crosscutting solutions to military health threats. The FY19 appropriation is $3M. To meet the intent of the award mechanism, applications submitted to the FY19 AIMM must address at least one of the Focus Areas listed below. Applications that will accelerate research toward innovations applicable to multi-domain operations and multi-domain operations in dense urban environments are encouraged but not required.

The FY19 AIMM Focus Areas are as follows:

• Algorithms/tools for decision support in a deployed or operational environment to: diagnose military-relevant disease, illness, or injury; prescribe mitigation and treatment strategies; and/or determine risk of Warfighter return to duty.

• Artificial Intelligence (AI)/deep learning for integrating heterogeneous data streams and analyzing data from wearables to support making informed healthcare decisions. Wearable sensor systems may pertain to, but are not limited to, the following or combinations of the following: infectious disease diagnosis; physiologic status monitoring; informing real-time casualty location and triage; and/or environmental monitoring.

• AI/deep learning for analyzing and interrogating large medical data sets to: identify patterns/predictors of disease, illness, or injury; and/or identify treatment outcomes.

Pre-app due: 26 July 2019

Full app due: 30 October 2019

Period of Performance: 18 months

Max Funding: $350,000

DHA-19-HSR - Health Services Research (HSR) Department of Defense

Description: The intent of this initiative is to foster HSR capability within the Military Health System (MHS) by fostering research that supports the transition to an integrated health system focused on the quadruple aim – improved health readiness, better health, better care, and lower cost. This research integrates epidemiologic, sociologic, economic and other analytic sciences to understand the relationships between need, demand, supply, use, and outcomes of health care. This announcement is intended to solicit both intramural and extramural health services research aligned with DHA priority research areas that support the MHS:

• Health System Merger and Consolidation - The impact of the merger and consolidation of the health system under a single management structure on health care utilization, quality, cost, health outcomes, manpower/staffing, or health readiness; including potential comparisons to similar activities within the private sector.

• Cost and Economics - Research on the factors that shape the healthcare system, drive demand and utilization as well as influence cost in either Purchased Care or Direct Care systems; impact of FY 2017 changes to the TRICARE benefit structure on utilization and cost that includes the introduction of co-pays and deductibles and expansion of benefits.

• Variation - Studies that examine the variation in quality, utilization, cost or outcomes within the MHS and the implications to healthcare.

• Health Readiness - Burden of disease and associated health and risk factors within the MHS and/or geographic market. Implications of disease burden as an indicator of medical readiness; potential to impact staffing, network utilization, and cost for direct care and/or purchased care; potential comparisons to private sector in similar markets.

• Outcomes - Outcomes studies examining variation associated health and risk factors at the health system, and/or geographic market or sub-population levels of the MHS with comparisons to private sector efforts. The impact of standardizing clinical practice through clinical practice guidelines (CPG), evidence-based practices, and process improvements, on the health of the population/sub-population. Specifically in following subject areas: a. Behavioral/mental health, b. Women, Infant, Children, c. Neuromuscular skeletal, d. Surgical services and oncology.

Letter of Intent due: 12 July 2019, 12:00PM EST

Full app due: 23 Aug 2019, 12:00PM EST

Period of Performance: variable, maximum 2 years beginning prior to 30 Sep 2019

Max Funding: Variable. Total available funds for grants under this announcement is capped at $10,000,000. It is anticipated that several awards will result from this funding opportunity announcement.

For more information, https://www.grants.gov/web/grants/view-opportunity.html?oppId=317512

W81XWH-19-HRRP-FRA – DoD Hearing Restoration Focused Program Award

Description: The HRRP was initiated in 2017 to support innovative and impactful research that pursues the treatment of auditory system injuries and the restoration of hearing. The HRRP will fund innovative research that has the potential to maximize operational performance, medical readiness, and quality of life for Service members, Veterans, and others living with significant auditory system injuries. Tinnitus or vestibular-related research is excluded. All applications to the FY19 HRRP FRA must address research in one or more of the following Focus Areas:

• Develop or validate techniques/methods to assess, diagnose, or treat auditory dysfunction as related to synaptopathy, hidden hearing loss, and central auditory processing disorders. Examples include, but are not limited to:

o Diagnostic tests that help differentiate sensory, neural, synaptic, and central processing disorders

o Diagnostic tools for use in forward or remote deployed settings to assess hidden hearing loss and to inform whether the individual’s hearing capability is sufficient to perform the duties of the job or work assignment

o Treatments for the various types of damage that result in the auditory dysfunction leading to decreased ability to adequately perform the duties of the job or work assignment

• Accelerate translation of biological regeneration/repair mechanisms into therapies that restore auditory function. Examples include, but are not limited to:

o Treatments to enhance synaptic plasticity

o Hair cell regeneration/repair/recovery

o Neural regeneration/repair/recovery

• Develop reliable in-vitro human models for evaluating hearing restoration therapies

Funding Level 1 supports exploratory, high-risk/high-reward research that is in the earliest stages of idea development.

Funding Level 2 supports the advancement of more mature research toward clinical translation.

Pre-app due: 16 July 2019

Full app due: 14 November 2019

Period of Performance: 2 years (Level 1), 3 years (Level 2)

Max Funding: The anticipated direct costs budgeted for the entire period of performance for an FY19 HRRP FRA Funding Level 1 will not exceed $250,000. The anticipated direct costs budgeted for the entire period of performance for an FY19 HRRP FRA Funding Level 2 will not exceed $1,000,000 or $1,250,000 for applications with a pilot clinical trial option.

For more information, https://www.grants.gov/web/grants/view-opportunity.html?oppId=315955

Announcement: Funding

Title:  ARMY RESEARCH OFFICE BROAD AGENCY ANNOUNCEMENT FOR FUNDAMENTAL RESEARCH

Type/Mechanism: Grant
Funding Opportunity Number: W911NF-17-S-0002-04

Application Open:  1 April, 2017 – 31 March 2022

Notes:  (See below for additional info)

Description: ARO is focused exclusively on extramural basic research, and is responsible for the vast majority of ARL’s extramural research programs and funding. Competencies are structured to create discovery, innovation, and transition of technologies leading to Power Projection Superiority, Information Supremacy, Lethality and Protection Superiority, and Soldier Performance Augmentation for Strategic Land Power Dominance. Proposals are expected to be for cutting-edge innovative research that could produce discoveries that would have a significant impact on enabling new and improved Army operational capabilities and related technologies. Specific research areas and topics of interest should be viewed as suggestive, rather than limiting. ARO is always interested in considering new innovative research concepts of relevance to the Army. Additional information about ARO areas of interest can be found on the ARL website:

http://www.arl.army.mil/www/default.cfm?page=29.

Research areas of interest include

·        Life Sciences (Neurophysiology of Cognition/Multisensory Synthesis)

·        Intelligent Systems for Improved Decision Making (sensing, perception, situation awareness)

·        Biomathematics (modeling sensory processing, disease processes)

·        International Opportunities: Human Dimension, Big Data

This Funding Opportunity Announcement is a BAA. It is continuously open for a 5-year period, from 01 April 2017 closing 31 March 2022. Proposals will be considered until and including the closing date of this announcement.

There are no specific funding restrictions associated with this BAA. The proposed duration for which support is requested should be consistent with the nature and complexity of the proposed activity.

For more information, https://www.grants.gov/web/grants/view-opportunity.html?oppId=292877

Announcement: Funding

Title:  CDMRP Peer Reviewed Medical Research Program

Type/Mechanism: Grant
Funding Opportunity Number: W81XWH-19-PRMRP

Pre Application Deadline:  14 Mar, 2019

Notes:  (See below for additional info)

Description: The vision of the FY19 PRMRP is to improve the health, care, and well-being of all military Service members, Veterans, and beneficiaries. The PRMRP challenges the scientific and clinical communities to address at least one of the FY19 PRMRP Topic Areas with original ideas that foster new directions along the entire spectrum of research and clinical care. The program seeks applications in laboratory, clinical, behavioral, epidemiologic, and other areas of research to advance knowledge in disease etiology, improve prevention, detection, diagnosis, treatment, and quality of life for those affected by a relevant disease or condition, and to develop and validate clinical care or public health guidelines. Tinnitus is an included topic area.

W81XWH-19-PRMRP-TTDA - CDMRP Peer Reviewed Medical Research Program Technology/Therapeutic Development Award (https://www.grants.gov/web/grants/view-opportunity.html?oppId=312037)

W81XWH-19-PRMRP-IIRA - CDMRP Peer Reviewed Medical Research Program Investigator-Initiated Research Award (https://www.grants.gov/web/grants/view-opportunity.html?oppId=312036)

W81XWH-19-PRMRP-DA - CDMRP PRMRP Discovery Award (https://www.grants.gov/web/grants/view-opportunity.html?oppId=312033)

W81XWH-19-PRMRP-CTA - CDMRP Peer Reviewed Medical Research Program Clinical Trial Award (https://www.grants.gov/web/grants/view-opportunity.html?oppId=312034)

W81XWH-19-PRMRP-FPA - CDMRP Peer Reviewed Medical Research Program Focused Program Award (https://www.grants.gov/web/grants/view-opportunity.html?oppId=312035)

CTA, FPA, IIRA, TTDA: Pre-Application Submission Deadline: 5:00 p.m. ET, March 14, 2019

DA: Pre-Application Submission Deadline: 5:00 p.m. ET, March 28, 2019

DA: Application Submission Deadline: 11:59 p.m. ET, April 11, 2019

CTA, FPA: Application Submission Deadline: 11:59 p.m. ET, July 2, 2019

IIRA, TTDA: Application Submission Deadline: 11:59 p.m. ET, July 11, 2019

Project periods/Amounts:

DA: 2 yrs/$200,000

IIRA: 3 yrs/$1.2M-$1.5M

TTDA: 3 yrs/$3M

CTA: 4 yrs/$ not predetermined

FPA: 4 yrs/$7.2M

Announcement: Grant
Title:  NIDCD Clinical Research Center Grant (P50/Clinical Trial Optional)
Award Organization: NICD
Type/Mechanism: Grant
Funding Opportunity Number: PAR-19-137
Award Amount: $1.5M/year 
Pre-proposals Due:  7 Jan, 2019
Full App Due: February 6, 2019; June 6, 2019; October 4, 2019; February 6, 2020; June 8, 2020; October 6, 2020; February 8, 2021; June 6, 2021; October 6, 2021


Notes: 
Description: The National Institute on Deafness and Other Communication Disorders (NIDCD) invites applications for Clinical Research Center Grants designed to advance the diagnosis, prevention, treatment, and amelioration of human communication disorders.  For this announcement, Clinical Research is defined as research involving individuals with communication disorders or data/tissues from individuals with a communication disorder. Examples of such research include but are not limited to, studies of the prevention, pathogenesis, pathophysiology, diagnosis, treatment, management or epidemiology of a disease or disorder of hearing, balance, smell, taste, voice, speech, or language.

Applications may propose a clinical trial but are not required (optional).  

Proposed research must meet 4 essential criteria:

1.  Must be clinical as defined above.
2.  Must have a well-defined central unifying theme consisting of three or more research projects with 1 or more supporting cores as appropriate; one core must be an administrative core.
3.  Each project must be unambiguously related to the central unifying theme. Synergistic and substantial interactions among the projects should be evident.
4.  Must provide multidisciplinary approaches to the central theme, defined as having research projects representing different disciplines, approaches and expertise. 

Additional Information: http://grants.nih.gov/grants/guide/pa-files/PAR-19-137.html

PA-19-053: NIH Exploratory/Developmental Research Grant Program (Clinical Trial Not Allowed) 

PA-19-054: NIH Exploratory/Developmental Research Grant Program (Clinical Trial Required) 

Description: The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. This program is intended to encourage new exploratory and developmental research projects. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

These studies should break new ground or extend previous discoveries toward new directions or applications. Applications for Exploratory/Developmental Research Grant awards should include projects distinct from those supported through the traditional R01 activity code. 

Open Date (Earliest Submission Date): January 16, 2019
Application Due Date(s): February 16, 2019
Expiration Date: January 8, 2022

Information: PA-19-053, PA-19-054

• Supports highly creative and conceptually innovative high-risk research with the potential to accelerate critical discoveries or major advancements that will significantly impact military health and medicine
• Supports novel research concepts and development of enabling technologies; not intended to support incremental advances on previous or ongoing work
• Supports applied research efforts that initiate or enhance potential game-changers; clinical trials are not allowed.
• Projects proposed should be relevant to at least one DoD medical research program area. Cross-cutting research projects with the potential to benefit multiple DoD medical research program areas are highly encouraged.
• Applications using synthetic or systems biology-based approaches are highly encouraged
• Preliminary data that are relevant to the proposed research are encouraged, but not required.
• Preproposal is required; application submission is by invitation only

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the final Program Announcement and General Application Instructions that will be available for electronic downloading from the Grants.gov website at https://grants.gov. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all USAMRMC funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.

Applications must be submitted through the federal government’s single-entry portal, Grants.gov. Submission deadlines are not available until the Program Announcement is released. For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org. For more information about other CDMRP-administered programs, please visit the CDMRP website (http://cdmrp.army.mil).

Point of Contact:

CDMRP Public Affairs
301-619-9783
usarmy.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@mail.mil