Current Funding Announcements

See below

Congressionally Directed Medical Research Programs (CDMRP) Hearing Restoration Research Program (HRRP) – FY23 Focused Research Award

HT9425-23-HRRP-FRA: Congressionally Directed Medical Research Programs (CDMRP) Hearing Restoration
Research Program (HRRP) – FY23 Focused Research Award

Description:

The FY23 HRRP FRA is intended to support promising research that accelerates drug

discovery and therapeutic development for hearing restoration after military-relevant auditory

system injury. Applications involving multidisciplinary collaborations among academia, industry,

the military Services, the VA, and other federal government agencies are highly encouraged. To meet

the intent of the award mechanism, all applications must address research in one or more of the

following Focus Areas:

• Improvement and acceleration of the translation of biological regeneration/repair mechanisms

into clinical applications. Research addressing the damage, repair, and regeneration of the

auditory system after military-relevant injuries is strongly encouraged.

• Development of diagnostic tests that differentiate sensory, neural, synaptic, and central

processing disorders, that may inform applicability and outcomes for current or future hearing

restoration therapeutics.

• Development of reliable in-vitro human models to facilitate the understanding, derivation,

and characterization of human auditory cells, and/or to facilitate the evaluation of hearing

restoration therapies.

Tinnitus or vestibular-related research is excluded.

Full award announcement: https://cdmrp.health.mil/funding/hrrp
About HRRP: https://cdmrp.health.mil/hrrp/default

Pre-Application Submission Deadline: August 15, 2023 (5:00 p.m. Eastern)
Application Submission Deadline: September 1, 2023 (11:59 p.m. Eastern)

Maximum funding/periods of performance

Funding level 1: $250,000/2 years

Funding level 2: $750,000/3 years

Funding level 3: $1M/3 years

FY23 Traumatic Brain Injury and Psychological Health Research Program (TBIPHRP)

HT9425-23-S-TBIPH: FY23 Traumatic Brain Injury and Psychological Health Research Program (TBIPHRP)

Description: The FY23 Defense Appropriations Act provides funding for TBIPHRP to support research

into the treatment, prevention, and detection of traumatic brain injury (TBI) and improved

psychological health. Research and development funded through this Broad Agency Announcement (BAA)

is intended for extramural applicants only. The TBIPHRP’s vision is to optimize the prevention,

assessment, and treatment of psychological health conditions and/or TBIs. Proposed research can be

aligned with TBI, psychological health, or both. The program seeks to fund research that

accelerates solutions to improve the health, well-being, and health care of Service Members, their

Families, Veterans, military beneficiaries, and the American public. Proposed research must be

relevant to active-duty Service Members, Veterans, military beneficiaries, and/or the American

public.

Applications must address one or more Focus Areas, not all of which will be applicable to every

award mechanism. Focus areas include:

• Understand: research will address knowledge gaps in foundational science, epidemiology, and

etiology of psychological health conditions and/or TBIs.

• Prevent and Assess: research will address the prevention or progression of psychological

health conditions and/or TBI through population, selective, and indicated prevention approaches,

including efforts that focus on primary prevention (including protection), screening, diagnosis,

and prognosis.

• Treat: research will address immediate and long-term treatments and improvements in systems

of care, including access to and delivery of healthcare services. Treatment topics may include

novel treatments and interventions, personalized medicine approaches, length and durability of

treatment, rehabilitation, relapse, and relapse prevention. Includes interventions focused on

sensory and motor dysfunction after brain injury.

Mechanisms, deadlines, and maximum funding/periods of performance:

Clinical trial award (CTA): pre-application June 15, 2023; full application September 28, 2023

• Funding level 1 $500,000/3 years; funding level 2 $2M/4 years; funding level 3 $4M/4 years

Focused program award (FPA): pre-application June 15, 2023; full application September 28, 2023

• $5M/4 years

Health services research award (HSRA): pre-application June 8, 2023; full application July 6, 2023

• $1.5M/4 years

Investigator initiated research award (IIRA): pre-application June 8, 2023; full application July 6, 2023

• $500,000/3 years

Translational research award (TRA): pre-application June 8, 2023; full application July 6, 2023

• $1M/4 years

For more information: https://cdmrp.health.mil/funding/tbiphrp

About TBIPHRP: https://cdmrp.army.mil/tbiphrp/default

For more information on types of funding opportunities offered and application strategies, review

the CDMRP Webinar Series: https://cdmrp.army.mil/pubs/Webinars/webinar_series

FY 23 Congressionally Directed Medical research programs (CDMRP) Joint warfighter medical research program (jwmrp) military medical research and development award (MMrda)

FY23 Congressionally Directed Medical Research Programs (CDMRP) Joint Warfighter Medical Research Program (JWMRP) Military Medical Research and Development Award (MMRDA)

Description: The JWMRP was initiated in 2012 to augment and accelerate high-priority Department of

Defense (DOD) and Service medical requirements and to continue prior year initiatives that are

close to achieving their objectives and yielding a benefit to military medicine. The ultimate goal

of the program is to expedite the delivery of highly impactful medical solutions to Service Members

and Military Health System (MHS) beneficiaries. Funds from the JWMRP shall not be used for new

projects or for basic research.

To be eligible for JWMRP funding, applicants must have already received DOD core or DOD

Congressional Special Interest prior year funding (including DOD Small Business Innovation

[SBIR]/Small Business Technology Transfer [STTR] awards) for the same project proposed for

continuation under this MMRDA. Projects funded through this appropriation are expected to benefit

both civilian and military communities, with particular focus on initiatives that impact our

forward deployed Forces and rehabilitation efforts for injured military.

Focus Areas include:

•Operational Medicine and Readiness

o Research aimed toward injury prevention, rapid return-to-duty capabilities, and rehabilitation

solutions to maintain Service Member readiness (musculoskeletal and neurosensory)

o Criteria and injury prediction models for ballistic/blast and/or accelerative events from

loading regimes seen with current and likely future weapons systems, with the goal of informing the

development of more effective personal protective equipment

o Innovative strategies and technologies that may include medical devices, pharmaceuticals,

rehabilitation strategies, and regenerative medicine-based approaches, to prevent, assess,

diagnose, treat, restore, maintain, and/or rehabilitate sensory system (vision, hearing, and

balance) function due to combat-related sensory injuries

Find information for extramural and intramural applicants at: https://cdmrp.health.mil/funding/jwmrp

Pre-Application (Preproposal) Deadline: June 15, 2023

Application Deadline: September 7, 2023

Maximum funding: $2.3 million ($3.5 million for Clinical Research/Trial Option)

Maximum period of performance: 3 years

CDMRP Help Desk: help@eBRAP.org

(R01 Clinical Trial Not Allowed): Bioengineering Research Grants (BRG)

Description: The goal of the bioengineering research grant (BRG) program is to foster development of innovative technologies, methods, tools, models or designs that have the potential for significant impact on biomedical research by infusing principles and concepts from quantitative sciences. This opportunity encourages applications that: 1) apply a multidisciplinary approach to solve biomedical problems; and 2) develop, integrate, optimize, validate, translate or accelerate adoption of promising tools, methods, and techniques for a specific research or clinical problem in basic, translational, and/or clinical science and practice.

Significant projects may include, but are not limited to: development, validation, and translation of promising modalities for the disease continuum, including tools for risk prediction, screening, prevention, detection, diagnosis, disease progression, intervention, monitoring treatment response, prognosis, or survival; development of quantitative, predictive models of complex biological systems; integration and optimization of technologies that significantly increase sensitivity, specificity, positive predictive value, negative predictive value, efficiency, or throughput of analysis to address unsolved biological or medical questions; in vitro and in vivo models, cell/tissue culture systems and organoids that closely mimic physiological conditions and allow mechanistic studies or engineering and testing of delivery systems, molecules/cells/tissues for therapeutic purposes, therapeutics, implants, and prosthetics that may improve treatment and healthcare.

Overall impact of these advances may include improving our understanding of molecular mechanisms, reducing disparities in access to care, promoting wellness and independent living, increasing access to and utility of technologies to improve quality of life, reducing the cost and complexity of procedures, and/or increasing throughput, sensitivity, and specificity of diagnostic tests.

NIH component participants include the National Institute on Deafness and Other Communication Disorders (NIDCD). Investigators are encouraged to contact the designated Scientific/Research contacts for individual institute focus areas that will be supported. For NIDCD, this is Nancy Freeman, Ph.D., (301) 402-3458, freemann@mail.nih.gov

Open Date (Earliest Submission Date): October 01, 2022

Expiration Date: September 08, 2025

Maximum Project Period: 5 years

Maximum Amount: Application budgets are not limited but need to reflect the actual needs of the proposed project.

Additional Information: https://grants.nih.gov/grants/guide/pa-files/PAR-22-242.html

Companion Funding Opportunity: PAR-22-243 (R01 Clinical Trial Optional) https://grants.nih.gov/grants/guide/pa-files/PAR-22-243.html

BRAIN Initiative: Targeted BRAIN Circuits Projects – Targeted BCP (R01 Clinical Trial Not Allowed)

RFA-NS-22-026: BRAIN Initiative: Targeted BRAIN Circuits Projects – Targeted BCP (R01

Clinical Trial Not Allowed)

Description: This FOA solicits applications for research projects that seek to understand how

circuit activity gives rise to mental experience and behavior using innovative, methodologically-

integrated approaches. The goal is to support adventurous projects that can realize a potentially

transformative outcome within 5 years. Applications are expected to address circuit function in the

context of specific behaviors or neural systems, such as sensation, perception, attention,

reasoning, intention, decision-making, emotion, navigation, communication, or homeostasis. Projects

should link theory, data analysis, and/or computational approaches to experimental design and

should produce predictive models (conceptual or quantitative).

Projects should aim to improve the understanding of circuits of the central nervous system by

systematically controlling stimuli and/or behavior while actively recording and/or manipulating

dynamic patterns of neural activity. Diverse species or experimental systems and a cross-

species/comparative approach are welcome and should be chosen based on their power to address the

specific question at hand and to reveal generalizable and fundamental neuroscience principles.

Targeted BRAIN Circuit Project R01 awards will support an individual laboratory or a small

multi-PD/PI team. Projects should reflect the NIH BRAIN Initiative interests of the application of

cutting-edge methodologies to understand central nervous system circuit function and

dynamics at cellular and sub-second levels of resolution in ethologically relevant behaviors of an

organism or a well-defined neural system. Applications should offer specific, feasible, and

potentially transformative research goals as endpoints within a 5-year term

Representative topics include: Innovative approaches to understand network coding of sensory

information and/or multi-sensory integration, at multiple stages of processing, in response to

naturalistic inputs and perceptual contexts.

Letter of Intent due date(s) 30 days prior to the application due date

Application due dates: June 1, 2022; July 1, 2022; October 6, 2022; June 30, 2023; October 4,

2023; June 28, 2024; October 2, 2024

Maximum project period: 5 years

Funding amount: the BRAIN Initiative intends to commit up to an estimated total of $15 M per year

to fund 20 awards.

Information: https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-22-026.html

NIDCD Research Grants for Translating Basic Research into Clinical Tools (R01 Clinical Trials Optional)

RFA-DC-22-001: NIDCD Research Grants for Translating Basic Research into Clinical Tools (R01 Clinical Trials Optional)

NIH - National Institute on Aging (NIA) and National Institute on Deafness and Other Communication

Disorders (NIDCD)

Description: This Funding Opportunity Announcement (FOA) is intended to provide an avenue for basic

scientists, clinicians and clinical scientists to jointly initiate and conduct translational

research projects which translate basic research findings into clinical tools for better human

health. The scope of this FOA includes a range of activities to encourage translation of basic

research findings which will impact the diagnosis, treatment and prevention of communication

disorders. Connection to the clinical condition must be clearly established and the outcomes of

the grant must have practical clinical impact.

Possible goals include, but are not limited to:

• Biochemical, electrophysiological and behavioral assays to enhance diagnostic capabilities.

• Pharmacology, toxicity, and pharmacokinetic for candidate therapeutics that have demonstrated

potential for the treatment of communication disorders.

• Preclinical animal research for dosage studies and toxicity when a subsequent Phase I/II

clinical trial is planned.

• Translation of new tools and techniques for better diagnostics or therapeutics, including but

not limited to, neuroprosthetic devices, drug delivery devices, neuro-electrical stimulators and

recording devices.

• Translation of laboratory-based screening tests, including biomarkers into improved ways to

identify individuals at risk for a communication disorder to allow for early intervention.

• Translation of published basic research findings into new clinical tools to better target the

treatment to the individual patient and to better predict patient response or prognosis.

• Translation of discoveries from biological, psychological, social sciences and other related

areas into innovative prevention and treatment paradigms and processes.

• Modification of laboratory measures of function or laboratory treatment protocols for use in

clinical settings.

Open Date (Earliest Submission Date): September 17, 2021

Letter of Intent Due Date(s): 30 days prior to the application due date

Application Due Date(s): October 20, 2021; June 20, 2022; February 22, 2023; October 18,

2023; June 20, 2024

Maximum Project Period: 5 years

Maximum Amount: NIDCD anticipates funding an estimated 2-3 awards in fiscal year 2022 for a total

of $1,500,000.

additional Information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DC-22-001.html

Open/Active DoD Broad Agency Announcements

U.S. Military Academy Broad Agency Announcement - W911NF-20-S-0008: This BAA was released April 1, 2020, and is open until March 31, 2025. It seeks proposals for cutting- edge innovative research that could produce discoveries with significant impact to enable new and improved Army technologies and related operational capabilities in the areas of socio-cultural; information technology; ballistics, weapons and protections; energy and sustainability; materials, measurements, and facilities; unmanned systems and space; human support systems; and artificial intelligence, machine learning, and quantum technologies. The human support systems focus includes biomechanical engineering to enhance soldier readiness (human performance optimization, injury prediction/prevention, physical and cognitive augmentation, Return-to-Duty metrics, functional influence of prosthetics/exoskeletal devices) and wearable technologies and sensors to inform performance decisions (e.g., monitoring/assessment, injury prevention, recovery times).

See: Military Academy BAA

Research Interests of the Air Force Office of Scientific Research

Announcement: BAA-AFRL-AFOSR-2016-0007
Award Organization: Air Force Office of Scientific Research
Type/Mechanism: Grant
Activity Code:
Web Site: DoD: http://www.grants.gov/web/grants/view-opportunity.html?oppId=285269
Award Amount: $200,000 - $400,000 encouraged; $7.5M max

PoP: 5 years
Restrictions: None
Rolling Annual Programs: Open until Superseded
Pre-Application Due: Open until superseded
Full App Due: Open until superseded
Notes: For the sensory systems portion of the portfolio a goal is to pursue new capabilities in acoustic analysis, to enhance the intelligibility and usefulness of acoustic information. The primary approach is to discover, develop, and test principles derived from an advanced understanding of cortical and sub-cortical processes in the auditory brain. Included are efforts to model and control effects of noise interference and reverberation, understand the psychoacoustic basis of informational masking, develop new methods for automatic speech detection, classification, and identification, and enable efficient 3D spatial segregation of multiple overlapping acoustic sources.

Research

Quick Fact

#29

Hearing is the process of changing sound waves into electrical signals that the brain interprets as specific sounds.