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Pharmaceutical Interventions for Hearing Loss (PIHL) Working Group

There are currently no FDA-approved pharmaceuticals indicated for prophylaxis or treatment of hearing loss or tinnitus. Several promising agents are already in clinical trials, however, with many more in preclinical development. The HCE has organized a working group known as the Pharmaceutical Interventions for Hearing Loss, or PIHL group, which is dedicated to advancing this field of biomedical research.

Bringing together experts from across the DoD, VA, academia, and industry, the PIHL group coordinates subject matter experts to compile, develop, and disseminate current and comprehensive understanding of:

The state of the science,  including preclinical research, ongoing clinical trials, and new study results,
Evidence-based research methodology standards, and
Capability-based requirements for technology transition to the DoD.

 

The PIHL group focuses its efforts through subcommittees formed around relevant topics

 

Current topics:

Ototoxicity

Patient-Monitoring/Therapeutic-Efficacy Parameters

Drug Delivery Methods

Ototoxic and Therapeutic Compounds (OTiC) Database Development

 

Additional topics:

Noise

Temporary Threshold Shift/Permanent Threshold Shift

Patient/Provider Education Toolkit

Vestibular Disease Targeting

Genetics/Genomics

RELEVANT DOCUMENTS

PIHL Newsletters

PIHL Research Guidance

PIHL Group Publications

PIHL WORKING GROUP CONTACT INFORMATION

Dr. Kathryn Marshall:  Kathryn.E.Marshall2.ctr@mail.mil

Dr. Julieta Scalo:  J.Scalo@posteo.net

 

Quick Fact

#21

No two ears are the same, which is important to keep in mind when ensuring proper fit for hearing protective devices. During hearing protection testing, there is a <2mm difference in insertion depth between eighty-five percent of subjects’ left and right ears.

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The Hearing Center of Excellence fosters and promotes the prevention, diagnosis, mitigation, treatment, rehabilitation and research of hearing loss and auditory injury. It supports the development, exchange and adoption of best practices, research, measures of effectiveness and clinical care guidelines to reduce the prevalence and cost of hearing loss and tinnitus among Warriors and Veterans. Read more

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