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Frontiers in Neuroscience, Cellular Mechanisms of Ototoxicity

Frontiers in Neuroscience,  Cellular Mechanisms of Ototoxicity

1.              Editorial: Cellular Mechanisms of Ototoxicity

Peter S. Steyger, Lisa L. Cunningham, Carlos R. Esquivel, Kelly L. Watts and Jian Zuo.  Published on 27 March 2018; Front. Cell. Neurosci. doi: 10.3389/fncel.2018.00075

2.              Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide-Treated Mice

Shin Hye Kim, Gaon Jung, Sangjae Kim and Ja-Won Koo. Published on 19 January 2018, Front. Cell. Neurosci. doi: 10.3389/fncel.2018.00003

3.              Inhibition of Mitochondrial Division Attenuates Cisplatin-Induced Toxicity in the Neuromast Hair Cells

Jonathon W. Vargo, Steven N. Walker, Suhasini R. Gopal, Aditi R. Deshmukh, Brian M. McDermott Jr., Kumar N. Alagramam and Ruben Stepanyan Zuo.       Published on 12 December 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00393

4.              Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity         

Meiyan Jiang, Farshid Taghizadeh and Peter S. Steyger. Published on 21 November 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00362

5.              Cyclodextrins and Iatrogenic Hearing Loss: New Drugs with Significant Risk

Mark A. Crumling, Kelly A. King and R. Keith Duncan.  Published on 08 November 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00355

6.              Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection         

Sandeep Sheth, Debashree Mukherjea, Leonard P. Rybak and Vickram Ramkumar. Published on 27 October 2017. Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00338

7.              Partial Aminoglycoside Lesions in Vestibular Epithelia Reveal Broad Sensory Dysfunction Associated with Modest Hair Cell Loss and Afferent Calyx Retraction 

David R. Sultemeier and Larry F. Hoffman.  Published on 27 October 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00331

8.              Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity

Chao-Hui Yang, Zhiqi Liu, Deanna Dong, Jochen Schacht, Dev Arya and Su-Hua Sha. Published on 24 October 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00315

9.              PI3K and Inhibitor of Apoptosis Proteins Modulate Gentamicin- Induced Hair Cell Death in the Zebrafish Lateral Line           

Heather Wiedenhoft, Lauren Hayashi and Allison B. Coffin.  Published on 18 October 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00326

10.           Towards the Prevention of Aminoglycoside-Related Hearing Loss          

Mary E. O’Sullivan, Adela Perez, Randy Lin, Autefeh Sajjadi, Anthony J. Ricci and Alan G. Cheng. Published on 18 October 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00325

11.           Aminoglycoside-Induced Cochleotoxicity: A Review     

Meiyan Jiang, Takatoshi Karasawa and Peter S. Steyger.  Published on 09 October 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00308

12.           Interleukin-10 Attenuates Hypochlorous Acid-Mediated Cytotoxicity to HEI-OC1 Cochlear Cells          

Martin Mwangi , Sung-Hee Kil, David Phak, Hun Yi Park, David J. Lim, Raekil Park and Sung K. Moon.  Published on 06 October 2017.  Front. Cell. Neurosci.  doi: 10.3389/fncel.2017.00314

13.           Protein Synthesis Inhibition and Activation of the c-Jun N-Terminal Kinase Are Potential Contributors to Cisplatin Ototoxicity

Brian D. Nicholas , Shimon Francis , Elizabeth L. Wagner , Sibo Zhang and Jung-Bum Shin.  Published on 27 September 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00303

14.           Magnetic Nanoparticle Mediated Steroid Delivery Mitigates Cisplatin Induced Hearing Loss

Bharath Ramaswamy , Soumen Roy , Andrea B. Apolo , Benjamin Shapiro and Didier A. Depireux.  Published on 13 September 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00268

15.           Hydrogen Inhalation Protects against Ototoxicity Induced by Intravenous Cisplatin in the Guinea Pig

Anette E. Fransson , Marta Kisiel , Kristian Pirttilä , Curt Pettersson, Pernilla Videhult Pierre and Göran F. E. Laurell.  Published on 13 September 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00280

16.           MicroRNAs in Hearing Disorders: Their Regulation by Oxidative Stress, Inflammation and Antioxidants

Kedar N. Prasad and Stephen C. Bondy.  Published on 11 September 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00276

17.           d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

Nerissa K. Kirkwood , Molly O'Reilly , Marco Derudas , Emma J. Kenyon , Rosemary Huckvale, Sietse M. van Netten, Simon E. Ward, Guy P. Richardson and Corné J. Kros.  Published on 05 September 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00262

18.           Non-autonomous Cellular Responses to Ototoxic Drug-Induced Stress and Death

Shimon P. Francis and Lisa L. Cunningham.  Published on 23 August 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00252

19.           An Antioxidant Screen Identifies Candidates for Protection of Cochlear Hair Cells from Gentamicin Toxicity

Volker Noack, Kwang Pak , Rahul Jalota , Arwa Kurabi and Allen F. Ryan.  Published on 18 August 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00242

20.           Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss

Gilda M. Kalinec , Gwen Lomberk, Raul A. Urrutia and Federico Kalinec.  Published on 07 July 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00192

21.           Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival

Azadeh Jadali , Yu-Lan M. Ying and Kelvin Y. Kwan.  Published on 18 May 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00137

22.           Protecting Mammalian Hair Cells from Aminoglycoside-Toxicity: Assessing Phenoxybenzamine’s Potential

Paromita Majumder , Paulette A. Moore, Guy P. Richardson and Jonathan E. Gale.  Published on 18 April 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00094

23.           The Contribution of Immune Infiltrates to Ototoxicity and Cochlear Hair Cell Loss

Megan B. Wood and Jian Zuo.  Published on 12 April 2017.  Front. Cell. Neurosci. doi: 10.3389/fncel.2017.00106

Quick Fact


Noise-induced hearing loss, or NIHL, is one of the most common occupational injuries.

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